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Publications

  • Hui-Wen Chiu, Chun-Wei Chu, Chih-Chia Huang , Zi-Chun Chia , Yung-Li Wang , Yu-Hsuan Lee, "Polystyrene microplastics induce hepatic lipid metabolism and energy disorder by upregulating the NR4A1-AMPK signaling pathway." Environmental Pollution (2025): 125850.

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  • Bao-Hong Lee, Yi-Ching Lin, Yu-Juan Zheng, Tang-Long Shen, Ting-Yu Cheng, Chih-Chia Huang , Wei-Hsuan Hsu, "Nanoplastics indirectly compromise lettuce growth in hydroponic systems via microbial extracellular vesicles derived from Curvibacter fontanus", Journal of Hazardous Materials,2024, 136457

  • Fei-Ting Hsu, Ying-Tzu Chen, Yu-Cheng Chin, Li-Chan Chang, Shu-Chin Chiang, Li-Xing Yang, Hua-Shan Liu, Po-Fu Yueh,  Hsiung-Lin Tu,  Ruei-Yu He, Long-Bin Jeng, Woei-Cherng Shyu, Shang-Hsiu Hu,  I-Tsang Chiang, Yu-Chang Liu, Yi-Chun Chiu, Guan-Chun Wu,  Ching-Ching Yu, Wen-Pin Su, Chih-Chia Huang, "Harnessing the Power of Sugar-Based Nanoparticles: A Drug-Free Approach to Enhance Immune Checkpoint Inhibition Against Glioblastoma and Pancreatic Cancer", ACS Nano 2024, 18, 42, 28764–28781.

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  • Li-Chan Chang, Yu-Cheng Chin, Ping-Ching Wu, Yu-Feng Wei, Hung-Chang Wu, Ting-Yu Cheng, Yin-Fen Liu, Chih-Chia Huang, Wen-Pin Su, "Polymeric nano-formulation of spectrum selective RTK inhibitor strengthens anti-cancer effects via immune remodeling by endoplasmic reticulum stress-modulating mitochondrial metabolism", Nano today, 2024, 54, 102070.

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  • Li-Xing Yang, Yi-Hsin Lai, Chun In Cheung, Zhi Ye, Tzu-Chi Huang, Yu-Chin Wang, Yu-Cheng Chin, Zi-Chun Chia, Ya-Jyun Chen, Meng-Jia Li, Hsiu-Ying Tseng, Yi-Tseng Tsai, Zhi-Bin Zhang, Kuan-Hsu Chen, Bo-Yang Tsai, Dar-Bin Shieh, Nan-Yao Lee, Pei-Jane Tsai*, Chih-Chia Huang*, "Novel metal peroxide nanoboxes restrain Clostridioides difficile infection beyond the bactericidal and sporicidal activity", Bioeng. Transl. Med, 8, e10593, 2023.

  • Tharmaraj Vairaperumal, Chih-Chia Huang, and Ping-Yen Liu*, "Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers", ACS Appl. Bio Mater, 6, 7, 2591–2613, 2023.

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  • Zi-Chun Chia , Yi-Lun Chen , Cheng-Hsun Chuang , Chou-Hsun Hsieh , Ya-Jyun Chen , Kuan-Hsu Chen , Tzu-Chi Huang , Mei-Chin Chen* , and Chih-Chia Huang *, "Polyphenol-assisted assembly of Au-deposited polylactic acid microneedles for SERS sensing and antibacterial photodynamic therapy", Chemical Communications, 59, 6339 - 6342, 2023.     

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  • Yu-Cheng Chin , Li-Xing Yang , Fei-Ting Hsu , Che-Wei Hsu , Te-Wei Chang , Hsi-Ying Chen , Linda Yen-Chien Chen , Zi Chun Chia , Chun-Hua Hung , Wu-Chou Su , Yi-Chun Chiu* , Chih-Chia Huang* , and Mei-Yi Liao* , "Iron oxide@chlorophyll clustered nanoparticles eliminate bladder cancer by photodynamic immunotherapy-initiated ferroptosis and immunostimulation", Journal of Nanobiotechnology, 20, 373, 2022.

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  • Syue-Liang Lin , Chen-Yuan Chung , Zih-Ting Chen , Chih-Chia Huang , Yun-Zhen Li , Eric Yi-Hsiu Huang & Huihua Kenny Chiang , "Observation and identification of autofluorescent urine crystals may be linked to a sign of urolithiasis", Urolithiasis 50, 535–543 (2022).

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  • Li‑Xing Yang , Yu‑Cheng Liu , Chang‑Hui Cho , Yi‑Rou Chen , Chan‑Shan Yang , Yin‑Lin Lu , Zhiming Zhang , Yi‑Tseng Tsai , Yu‑Cheng Chin , Jiashing Yu , Hsiu‑Min Pan , Wei‑Rou Jiang , Zi‑Chun Chia , Wei‑Shiang Huang , Yu‑Lin Chiu , Chun‑Kai Sun , Yu‑Ting Huang , Li‑Ming Chen , Ken‑Tsung Wong , Han‑Min Huang , Chih‑Hsin Chen* , Yuan Jay Chang* , Chih‑Chia Huang* and Tzu‑Ming Liu*,  "A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges", Journal of Nanobiotechnology, 20, 311, 2022. 

  • Wen-Pin Su* , Li-Chan Chang , Wei-How Song , Li-Xing Yang , Liu-Chun Wang , Zi-Chun Chia , Yu-Cheng Chin , Yan-Shen Shan , Chih-Chia Huang* , and Chen-Sheng Yeh* ,  "Polyaniline-Based Glyco-Condensation on Au Nanoparticles Enhances Immunotherapy in Lung Cancer", ACS Appl. Mater. Interfaces, 2022, 14, 21, 24144–24159. 

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  • Te-Wei Chang, Han Ko, Wei-Shang Huang, Yi-Chun Chiu, Li-Xing Yang, Zi-Chun Chia, Yu-Cheng Chin, Ya-Jyun Chen, Yi-Tseng Tasi, Che-Wei Hsu, Chia-Ching Chang, Pei-Jane Tasi, Chih-Chia Huang*, "Tannic acid-induced interfacial ligand-to-metal charge transfer and the phase transformation of Fe3O4 nanoparticles for the photothermal bacteria destruction", Chemical Engineering Journal, 2022, 428, 131237.

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  • Zi-Chun Chia, Li-Xing Yang, Ting-Yu Cheng, Ya-Jyun Chen, Horng-Long Cheng, Fei-Ting Hsu, Ying-Jan Wang, Yu-Ying Chen, Tzu-Chi Huang, Yi-Syun Fang, and Chih-Chia Huang*, "In Situ Formation of Au-Glycopolymer Nanoparticles for Surface[1]Enhanced Raman Scattering-Based Biosensing and Single-Cell Immunity", ACS Appl. Mater. Interfaces, 2021, 13, 44, 52295–52307. 

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  • Tzu-Chi Huang, Hsiao-Chieh Tsai, Yu-Cheng Chin, Wei-Shan Huang, Yi-Chun Chiu, Tzu-Chun Hsu, Zi-Chun Chia, Tzu-Chiao Hung, Chih-Chia Huang*, and Yi-Ting Hsieh*,"Concave Double-Walled AgAuPd Nanocubes for Surface-Enhanced Raman Spectroscopy Detection and Catalysis Applications", ACS Appl. Nano Mater. 2021, 4, 10, 10103–10115.

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  • Su-Hua Yang, Hao-Yu Zhang, Chih-Chia Huang*, Yi-Yan Tasi and Shun-Ming Liao, "Red Zn2SiO4:Eu3+ and Mg2TiO4:Mn4+ nanophosphors for on-site rapid optical detections: Synthesis and characterization", Applied Physics A, 2021, 127, 588.

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  • Yung-Li Wang, Yu-Husan Lee, Yung-Ho Hsu, I-Jen Chiu, Cathy Chia-Yu Huang, Chih-Chia Huang, Zi-Chun Chia, Chung-Pei Lee, Yung-Feng Lin and Hui-Wen Chiu, "The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice", Environmental Health Perspectives, 2021, 102, 57003.

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  • Yung-Li Wang, Yu-Husan Lee, Yung-Ho Hsu, I-Jen Chiu, Cathy Chia-Yu Huang, Chih-Chia Huang, Zi-Chun Chia, Chung-Pei Lee, Yung-Feng Lin and Hui-Wen Chiu, "The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice", Environmental Health Perspectives, 2021, 102, 57003.

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  • I-Ling Hsu, Fang-Hao Yeh, Yu-Cheng Chin, Chun-In Cheung, Zi-Chun Chia, Li-Xing Yang, Ya-Jyun Chen, Ting-YuCheng, Shu-Pao Wu, Pei-Jane Tsai*, Nan-Yao Lee*, Mei-Yi Liao*, Chih-Chia Huang*, ''Multiplex antibacterial processes and risk in resistant phenotype by high oxidation-state nanoparticles: new killing process and mechanism investigations '',Chemical Engineering Journal, 2021, 409, 128266.

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  • Yi-Jui Chen, Wen-Huei Chang, Chia-Ying Li, Yi-Chun Chiu, Chih-Chia Huang*, Chun-Hung Lin, ''Direct synthesis of monolayer gold nanoparticles on epoxybased photoresist by photoreduction and applicationto surface-enhanced Raman sensing '', Materials and Design, 2021, 197, 109211.

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  • Chun-Wei Lin, Shih-Hui Chang, Chih-Chia Huang, Chun-Hung Lin, ''Plasmonic nanocavities fabricated bydirected self-assembly lithography and nanotransfer printing and used as surface-enhanced Raman scattering substrates '', Microelectronic Engineering , 2020, 227, 111309.

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  • Yao-Tzu Yang, I-Ling Hsu, Ting-Yu Cheng, Wen-Jeng Wu, Chien-Wei Lee, Tsung-Ju Li, Chun-In Cheung, Yu-Cheng Chin, Hsiao-Chien Chen, Yi-Chun Chiu*, Chih-Chia Huang*, Mei-Yi Liao*, ''Off-Resonance SERS Nanoprobe-Targeted Screen of Biomarkers for Antigens Recognition of Bladder Normal and Aggressive Cancer Cells'', Anal. Chem, 29, 2019, 91, 13, 8213–8220.

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  • Chien-Wei Lee, Pei-Chun Wu, I-Ling Hsu, Tzu-Ming Liu,* Wai-How Chong, Cheng-Ham Wu, Tsung-Yuan Hsieh, Lun-Zhang Guo, Yu Tsao, Po-Ting Wu, Jiashing Yu, Pei-Jane Tsai, Huei-Sheng Huang, Yu-Chun Chuang, and Chih-Chia Huang*, ''New templated Ostwald ripening process of mesostructured FeOOH for third-harmonic-generation bioimaging'' , Small, 2019, 1805086 *selected as back cover

  • Pei‐An Lo, Yi‐Hsiu Huang, Yi‐Chun Chiu, Li‐Ci Huang, Jia‐Lun Bai, Shu‐Han Wu, Chih‐Chia Huang*, Huihua Kenny Chiang*, ''Automatic Raman spectroscopic urine crystal identification system using fluorescent image‐guided 2D scanning platform with Fe3O4 crystal violet nanoclusters'',  J Raman Spectrosc. 2018;50:34-40.

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  • Wei-Jhe Syu, Chih-Chia Huang, Jong-Kai Hsiao, Yao-Chang Lee, Yu-Tsang Huang, Parthiban Venkatesan, Ping-Shan Lai*, ''Co-precipitation Synthesis of Near-infrared Iron Oxide Nanocrystals on Magnetically Targeted Imaging and Photothermal Cancer Therapy via Photoablative Protein Denature '',Nanotheranostics , 25, 2019

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  • Wei-En Hong,   I-Ling Hsu,   Szu-Yung Huang,   Chien-Wei Lee,  Han Ko,  Pei-Jane Tsai,  Dar-Bin Shiehcd and Chih-Chia Huang*, "Assembled growth of 3D Fe3O4@Au nanoparticles for efficient photothermal ablation and SERS detection of microorganisms",  Journal Materials of Chemistry B, 2018, 6, 5689--5697.  *selected as inside cover 

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  • Chien-Wei Lee, Han Ko and Chih-Chia Huang*, "Invisible ink-assisted pattern- and written surface-enhanced Raman scattering substrates for versatile chem-/biosensing platforms" ,Green Chem, 2018,20, 5318-5326.

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  • Wei-Shan Huang, I-Wen Sun, and Chih-Chia Huang*, "Promotion of SERS and Catalytic Activities with Bimetallic and Ternary Concave Nanolayers", Journal Materials of Chemistry A, 2018, 6, 13041–13049. 

  • Tzu-Ming Liu, João Conde, Tomasz Lipiński, Artur Bednarkiewicz, Chih-Chia Huang*, "Smart NIR linear and nonlinear optical nanomaterials for cancer theranostics: prospects in photomedicine", Progress in Materials Science , 2017, 88, 89–135.

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  • Chih-Chia Huang*, Pei-Hua Lin and Chien-Wei Lee, " OFF/ON galvanic replacement reaction for preparing divergent AuAg nano-hollow as a SERS-visualized drug delivery system in targeted photodynamic therapy", RSC Adv., 2016,6, 64494-64498.

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  • Joao Conde, Tzu-Ming Liu, Tomasz Lipiński, Artur Bednarkiewicz, and Chih-Chia Huang*, " Revisiting the classification of NIR absorbing/emitting Nanomaterials for in vivo bio-applications", NPG Asia Materials, 2016, 8, e295.

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  • Tsung-Ju Li, Chen-Min Chang, Po-Yang Chang, Yu-Chun Chuang, Chih-Chia Huang*, Wu-Chou Su and Dar-Bin Shieh,  "Handheld energy-efficient magneto-optical real-time quantitative PCR device for target DNA enrichment and quantification" NPG Asia Material, 2016, 8, e277.

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  • Pi-Tai Chou, Shang-Wei Chou, Chien-Liang Liu, Tzu-Ming Liu, Cheng-Ham Wu, Tsung-Yuan Hsieh, Pei-Chun Wu, Yu-Hsin Wang, Yi-An Chen, Chih-Chia Huang, Churng-Ren Wang, Hsieh-Chih Chen and Pai-Chi Li, "Infrared-active quadruple contrast FePt nanoparticles for multiple scale molecular imagin", biomaterials, 85, 2016, 54–64.

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  • Chih-Chia Huang and Tzu-Ming Liu, "Controlled Au-polymer nanostructures for multiphoton imaging, prodrug delivery, and chemo-photothermal therapy platforms", ACS Appl. Mater. Interfaces, 2015, 7, 45, 25259–25269.

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  • Po-Yang Chang, Chien-Liang Liu, Jia-Pu Xu, Wen-Chuan Kuo*, and Chih-Chia Huang*, "New insight on optical Fe3O4 nanoclusters promising for near infrared theranostic applications", Nanoscale, 2015,7, 12689-12697.

  • Yi-Chun Chiu, Po-An Chen, Po-Yang Chang, Cheng-Yang Hsu, Ching-Wei Tao, Chih-Chia Huang* and Huihua Kenny Chiang*, , "Enhanced Raman sensitivity and magnetic separation for urolithiasis detection using phosphonic acid-terminated Fe3O4 nanoclusters", J. Mater. Chem. B, 2015,3, 4282-4290.

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  • Jiashing Yu* , Che-Hao Hsu , Po-Yang Chang and Chih-Chia Huang*, "Development of Therapeutic Au-Methylene Blue Nanoparticles for Targeted Photodynamic Therapy of Cervical Cancer Cells", ACS Appl. Mater. Interfaces, 2015, 7, 1, 432–441.

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  • Tzu-Ming Liu, Jiashing Yu, C. Allen Chang, Arthur Chiou, Huihua Kenny Chiang, Yu-Chun Chuang, Cheng-Han Wu, Che-Hao Hsu, Po-An Chen and Chih-Chia Huang*, "One-step shell polymerization of inorganic nanoparticles and their applications in SERS/nonlinear optical imaging, drug delivery, and catalysis", Sci Rep, 4, 5593 (2014).

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  • Pei-Hsien Ting, Chih-Chia Huang and Meng-Lin Li, "NIR-activated iron oxides as a new multi-functional contrast agent of photoacoustic imaging", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89434E (3 March 2014).

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  • Mei-Yi Liao, Cheng-Ham Wu, Ping-Shan Lai, Jiashing Yu, Hong-Ping Lin, Tzu-Ming Liu* and Chih-Chia Huang*, "Surface States Mediated NIR Two-Photon Fluorescence of Iron Ox-ides for Nonlinear Optical Microscopy", Adv. Funct. Mater., 23: 2044-2051.

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  • Mei-Yi Liao, Ping-Shan Lai, Hsiu-Ping Yu, Hong-Ping Lin* and Chih-Chia Huang*, "Innovative ligand-assisted synthesis of NIR-activated iron oxide for cancer theranostics", Chem. Commun., 2012,48, 5319-5321.

  • Syu-Ming Lai, Jong-Kai Hsiao, Hsiu-Ping Yu, Chen-Wen Lu, Chih-Chia Huang, Ming-Jium Shiehd and Ping-Shan Lai, "Polyethylene glycol-based biocompatible and highly stable superparamagnetic iron oxide nanoclusters for magnetic resonance imaging", J. Mater. Chem., 2012,22, 15160-15167.

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